The Matrixyl peptide: Aging investigations

Lipopeptides, of which Matrixyl  is a kind, are molecules with fatty and amino acids. Based on animal studies, it has been termed a potential “anti-aging peptide” due to research findings that indicate it may stimulate the production of skin cell collagen and elastin.

Another example of a synthetic isomer is Matrixyl, which has the same formula as the original molecule but differs in atomic composition. Matrixyl 3000’s active ingredient is micro-collagen. 

Matrixyl peptide: What is it?

The synthetic peptide Matrixyl, also called palmitoyl pentapeptide-3, comprises two proteins hypothesised to promote the production of new elastin, collagen, and hyaluronic acid. Animal studies have suggested that it may work much better when mixed with other peptides.

Research on animal subjects, although not definitive, has indicated that the peptide Matrixyl may feed the organism’s stocks of glycosaminoglycan and fibroblasts, reinforcing the connective tissue and producing a vibrancy and restoration to the skin barrier.

Research indicates that Palmitoyl pentapeptide-3 products may improve skin cell strength and efficacy. Multiple investigations corroborate the findings of animal experiments, suggesting that Matrixyl-products may potentially stimulate collagen formation and improve the length and depth of wrinkles in the skin surface.

In addition to hastening wound healing, Matrixyl has been theorised to promote natural healing in the dermal layers. According to research, this is all because of cells called fibroblasts, which  appear to aid in wound adhesion and may promote faster healing in damaged tissue cells.

Matrixyl peptide: Mechanism of action

Scientists first found matrix peptides in two different lines of dermatological study. The first one looked for substances that hastened the healing of skin wounds. As of March 2024, the second determined the root cause of wrinkling in skin barriers.

Studies have postulated that Matrixyl peptide may promote wound healing by activating the skin’s deep layers to mend itself. According to similar research, Matrixyl seems to stimulate the skin’s matrix layers, including collagen, elastin, and fibronectin. Palmitoyl pentapeptide is believed to have anti-aging potential because it may activate these layers, which in turn helps the skin manufacture more collagen. Wrinkles are caused by the loss of collagen, which happens naturally over time. Based on findings in animal studies, scientists now speculate that the Matrixyl formula may inhibit this physiological aging process.

Investigations have purported that Matrixyl 3000 peptide might significantly reduce the appearance of wrinkles, drooping skin folds, and discoloration in mice. According to the study’s researcher, the skin appears tighter, firmer, and more robust.

Matrixyl peptide potential

Increased strength in the skin barrier, less sagging, and better hydration retention in the dermal layers are some of Matrixyl’s hypothesised potential downstream impacts, via its proposed action on a cellular level.

Matrixyl peptide and wrinkles

Findings imply that Matrixyl may impact the aging of cells in animals observed in experimental testing. Research indicates that hyaluronic acid production appeared to have increased by 267%, collagen IV synthesis by 327%, and total collagen synthesis by 117% in the research models observed.

Additionally, the research reported that fine lines seemed to have diminished almost entirely, and deep wrinkles appeared to have decreased by up to 50%. The results suggested that after just two weeks, all of the animals in the research had much fewer wrinkles. Researchers suggest combining Matrixyl and other cosmetic peptides to potentially act synergistically on the skin barrier.

Scientists have hypothesised that large concentrations of Matrixyl may enhance collagen production in the skin, which in turn may reduce the appearance of wrinkles and drooping skin. Animal studies have indicated that improving the extracellular matrix of the skin by reducing collagen breakdown and increasing collagen formation may help skin seem tighter, plumper, and smoother.

The ability of matrikines to stimulate the synthesis of elastin, collagen, and other skin macromolecules led to the development of peptides with similar potential.

Matrixyl peptide research studies

Animal studies have purported that this peptide may have strong anti-aging properties on cell division and protein production, and researchers are committed to learning more about it.

For this experimental study, 23 mice were given a topical application of Matrixyl at a concentration of 3%. Two months later, it was hypothesised to exhibit signs of enhanced collagen and hyaluronic acid synthesis, reduced the appearance of wrinkles and furrows, and suggested signs of better tone and elasticity.

If you are a certified researcher looking for the highest quality Matrixyl for your study, we suggest purchasing it online from a trustworthy vendor, such as Core Peptides. Please note that none of the substances mentioned in this paper have been approved for human or animal consumption.

The editorial unit

References

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[ii] Akhlaghi, Seyedeh Parinaz, and Watson Loh. “Interactions and Release of Two Palmitoyl Peptides from Phytantriol Cubosomes.” European Journal of Pharmaceutics and Biopharmaceutics 117 (August 2017): 60–67. doi:10.1016/j.ejpb.2017.03.022.

[iii] Jones RR, Castelletto V, Connon CJ, Hamley IW. Collagen stimulating effect of peptide amphiphile C16-KTTKS on human fibroblasts. Mol Pharm. 2013 Mar 4;10(3):1063-9. doi: 10.1021/mp300549d. Epub 2013 Feb 4. PMID: 23320752.

[iv] Kaczvinsky, J. R., Griffiths, C. E., Schnicker, M. S., & Li, J. (2009). Efficacy of anti-aging products for periorbital wrinkles as measured by 3-D imaging. Journal of cosmetic dermatology, 8(3), 228–233. https://doi.org/10.1111/j.1473-2165.2009.00444.x

[v] Errante F, Ledwoń P, Latajka R, Rovero P, Papini AM. Cosmeceutical Peptides in the Framework of Sustainable Wellness Economy. Front Chem. 2020 Oct 30;8:572923. doi: 10.3389/fchem.2020.572923. PMID: 33195061; PMCID: PMC7662462.