Epithalon: Melatonin, metastases and more

In preparation for their experimental research in cell aging, researchers from all over the globe are developing greater interest in the peptide Epithalon. Studies suggest the short peptide known as Epithalon may be responsible for activating telomerase and is speculated for its following possible functions:

• Cell longevity and relevance in anti-aging research and development
• Possible regulation of sleep cycles, improving sleep quality
• Potential antioxidant defense mechanisms
  

Substantial studies over many decades have attemted to evaluate this peptide in scientific settings, and researchers have easy access to information on the appropriate handling. We will discuss the potential action and profile of this substance. In addition, we will advise where researchers may get Epithalon online at a reasonable price.

Epithalon Peptide: What is it?

The tetrapeptide known as Epithalon is a synthetic compound composed of alanine, glutamic acid, aspartic acid, and glycine. The epithalamin, a crude polypeptide isolated from the pineal glands of bovines, is the source of this substance. Khavinson and colleagues first produced the pineal gland peptide in the early 1980s. The impact it is purported to have on cell lifespan have been the subject of research and theorisation since then.

Research indicates that because one strand of the replication fork lags behind the other, Epithalon may operate by increasing telomerase activity, which in turn may cause telomeres to lengthen. Telomeres are portions of DNA that prevent the ends of chromosomes from being removed during each replication cycle. The extension of telomeres has been suggested as a potential method for increasing cell life; however, the number of cell types investigated in research has been restricted. In general, studies of lymphocytes have produced more data on telomere length and lifespan than studies of other cell types.

To fulfill their scientific and educational objectives, licensed researchers can acquire research-grade Epithalon online. Buy peptides, Epithalon, and many other research compounds on the Biotech Peptides website.

Epithalon peptide potential

It is important to point out that the majority of the studies that have been done on Epithalon and epithalamin have been carried out in Russia, and there has been no independent validation of this research anywhere else. In addition, a significant portion of the research that has been published has not yet been translated into the English language.

Moreover, the concept that lengthening telomeres is equivalent to slowing the cell aging process is frequently exaggerated. This theory is dependent on the assumption that the length of telomeres in circulating lymphocytes may be utilised as a marker for the length of telomeres in cells. For this reason, we recommend that researchers planning research projects intending to evaluate epithalons in a preclinical setting maintain a level of skepticism. Some of the alleged properties of Epithalon include the following:

• A study by Rosenfeld and colleagues 2002 suggested that presenting Epithalon to mice with accelerated senescence may have resulted in an antimutagenic effect. After seeing that therapy with melatonin did not impact the levels of chromosomal abnormalities in the mice, the researchers employed the peptide to possibly reduce the levels of these aberrations.
• When introduced to telomerase-negative fetal fibroblast cultures, Khavinson et al. (2003) speculated that Epithalon may prolong longevity in cell populations and entire organisms via its telomerase activity. The findings of this study set the path for later research on anti-aging technologies that may evaluate Epithalon.
• Khavinson et al. (2003) conducted a study to evaluate the impact of epithalamin over two to three years. They speculated a 1.6-1.8 times reduction in mortality in the experimental compared to a control group. The epithalamion group also appeared to have lower incidences of coronary artery disease, hypertension, and osteoarthritis when compared to the control group.
• It was asserted by Korkushko et al. (2004) that epithalamin may boost melatonin synthesis. This is suggested to be accomplished by the peptide possibly manipulating the pineal gland’s activity to produce melatonin.
• The alleged antimetastatic action of Epithalon was suggested by Kossoy et al. (2006), who evaluated the peptide’s potential to slow down the formation of metastases from spontaneous tumors in female rodents that were ordinarily prone to developing cancers of the reproductive organs.
• Researchers hypothesised that the peptide may have dramatically increased neuron activity in the cerebral cortex of white rats. These results suggest the peptide may be relevant in research applications in the context of CNS activity deficits.
• According to Kozina et al. (2007), pineal gland peptides, including Epithalon, seem to effectively boost the antioxidant response in research models. According to researchers ‘ findings, Epithalamin generates direct antioxidant effects and increases the production of antioxidant enzymes such as superoxide dismutase and ceruloplasmin.
• Scientists indicated that Epithalon and melatonin may positively affect reproductive function in young and aged female rats subjected to detrimental environmental conditions such as light pollution. This was believed to be accomplished by positively using the hormones.

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References

[i] Epithalamin/Epithalon. (2022). Retrieved 2 May 2022, from https://www.alzdiscovery.org/uploads/cognitive_vital ity_media/Epithalamin-and-Epithalon-Cognitive-Vitality-For-Researchers.pdf

[ii] Epithalon monograph final – peptidesociety.org. https://peptidesociety.org/wp-content/uploads/2018/07/Epithalon-Monograph-Final.pdf

[iii] Khavinson VKh, Kuznik BI, Tarnovskaia SI, Lin’kova NS. [Peptides and CCL11 and HMGB1 as molecular markers of aging: literature review and own data]. Adv Gerontol. 2014;27(3):399-406. Russian. PMID: 25826983.

[iv] Korkushko OV, Khavinson VKh, Shatilo VB, Magdich LV. Effect of peptide preparation epithalamin on circadian rhythm of epiphyseal melatonin-producing function in elderly people. Bull Exp Biol Med. 2004 Apr;137(4):389-91. PMID: 15452611

[v] Kossoy G, Anisimov VN, Ben-Hur H, Kossoy N, Zusman I. Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice. In Vivo. 2006 Mar-Apr;20(2):253-7. PMID: 16634527

[vi] Kozina LS, Arutjunyan AV, Khavinson VKh. Antioxidant properties of geroprotective peptides of the pineal gland. Arch Gerontol Geriatr. 2007;44 Suppl 1:213-6. doi: 10.1016/j.archger.2007.01.029. PMID: 17317455

[vii] Korenevsky AV, Milyutina YP, Bukalyov AV, Baranova YP, Vinogradova IA, Arutjunyan AV. [Protective effect of melatonin and epithalon on hypothalamic regulation of reproduction in female rats in its premature aging model and on estrous cycles in senescent animals in various lighting regimes]. Adv Gerontol. 2013;26(2):263-274. Russian. PMID: 28976150

[viii]  Korkushko OV, Khavinson VKh, Shatilo VB, Antonyk[1]Sheglova IA. Peptide geroprotector from the pituitary gland inhibits rapid aging of elderly people: results of 15-year follow-up. Bull Exp Biol Med. 2011 Jul;151(3):366-9. English, Russian. doi: 10.1007/s10517-011-1332-x. PMID: 22451889.