Women can now treat period pain and PMS without drugs or hormones: Introducing nettle brain stimulation

Women’s health is often overlooked but Samphire Neuroscience is breaking barriers with its game-changing innovation, Nettle. This wearable device offers hormone-free PMS and period pain relief, blending advanced neurotechnology with a user-focused design to address the needs of women everywhere.

The inspiration behind nettle: A natural treatment for PMS and period pain

Samphire Neuroscience was founded by Em, a Harvard- and Oxford-trained neuroscientist, driven by the glaring gaps in research and solutions for women’s reproductive health. Inspired by countless personal stories and the lack of effective options for conditions like PMS, PMDD, and PCOS, Em envisioned a better way to ease the challenges women face every month.

Rather than relying on hormonal treatments with potential side effects, Samphire Neuroscience focused on creating a natural, science-backed solution that addressed the root causes of both pain and PMS symptoms. Em and her team worked closely with hundreds of women to design a device that is effective, practical, and easy to use.

Backed by over 30 years of clinical research and outperforming traditional treatments in their Triple-Blind, Randomised, Sham-Controlled clinical trial, Nettle is now the only scientifically validated solution on the market.

Addressing a long-ignored need for drug-free / natural period pain relief

For decades, women have had limited options for managing the physical and emotional toll of PMS and period pain. Conditions like endometriosis and PMDD remain under-researched and under-funded. Samphire Neuroscience took on the challenge of filling this void, combining neuroscience and advanced technology to develop Nettle.

This wearable device delivers targeted neurostimulation to address both physical pain and emotional symptoms. With clinical validation backing its effectiveness, Nettle is a rare breakthrough that offers real PMS pain relief in an area long overlooked by traditional medicine.

Why nettle stands out for menstrual cramp relief

What makes Nettle unique is its holistic approach. Unlike other products that treat pain or mood symptoms in isolation, Nettle addresses both. Using advanced hardware and software, the device delivers personalised PMS and pain relief treatment. Women wear Nettle for just 20 minutes a day during the five days leading up to their period, and its user-friendly design integrates with everyday life.

Besides its effectiveness, Nettle has a 90-day return policy, reflecting Samphire Neuroscience’s confidence in its product and commitment to customer satisfaction.

Samphire neuroscience’s recognition and achievements

Samphire Neuroscience’s work has not gone unnoticed. The founders were featured in Forbes 30 Under 30, and Nettle has won prestigious awards, including “Innovation of the Year” at MEDICA 2025 and “Women’s Health Innovation of the Year” in 2024. Coverage in major outlets like TechCrunch, Sustain Health, and UKTN has highlighted their mission to improve women’s health.

But the accolades go beyond headlines. The company has partnered with employee benefits platforms like Heka and Zest to further women’s health science, ensuring their work remains among the leaders in neurotechnology advancements.

Menstrual pain and PMS treatment from samphire neuroscience: A global impact

Currently focusing on the European market, Samphire Neuroscience is laying the groundwork for global expansion. Their vision goes beyond creating products—they aim to reshape the conversation around women’s health by integrating advanced neuroscience education and data analysis into their platform.

Nettle is more than a wearable; it’s a promise of empowerment. For the millions of women battling the debilitating effects of PMS and period pain, this hormone-free solution offers a future of comfort, relief, and renewed control over their lives.

With its fresh approach and dedication to women’s health, Samphire Neuroscience is proving that science and empathy can work together. Nettle isn’t just technology—it’s progress.

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Images: Samphire Neuroscience